Velio bocci biography of martin
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Abstract
The aim of this paper is to analyze why ozone can be medically useful when it dissolves in blood or in other biological fluids. In reviewing a number of clinical studies performed in Peripheral Arterial Diseases (PAD) during the last decades, it has been possible to confirm the long-held view that the inverted U-shaped curve, typical of the hormesis concept, is suitable to represent the therapeutic activity exerted by the so-called ozonated autohemotherapy. The quantitative and qualitative aspects of human blood ozonation have been also critically reviewed in regard to the biological, therapeutic and safety of ozone. It is hoped that this gas, although toxic for the pulmonary system during prolonged inhalation, will be soon recognized as a useful agent in oxidative-stress related diseases, joining other medical gases recently thought to be of therapeutic importance. Finally, the elucidation of the mechanisms of action of ozone as well as the obtained results in PAD may encourage clinical scientists to evaluate ozone therapy in vascular diseases in comparison to the current therapies.
Introduction
Ozone is a double-faceted gas. It has a crucial protective relevance in partially blocking mutagenic and carcinogenic UV radiations emitted by the sun (wavelengths of 100-
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Mechanisms of Action Involved in Ozone Therapy: Is healing induced via a mild oxidative stress?
Abstract
The potential mechanisms of action of ozone therapy are reviewed in this paper. The therapeutic efficacy of ozone therapy may be partly due the controlled and moderate oxidative stress produced by the reactions of ozone with several biological components. The line between effectiveness and toxicity of ozone may be dependent on the strength of the oxidative stress. As with exercise, it is well known that moderate exercise is good for health, whereas excessive exercise is not.
Severe oxidative stress activates nuclear transcriptional factor kappa B (NFκB), resulting in an inflammatory response and tissue injury via the production of COX2, PGE2, and cytokines. However, moderate oxidative stress activates another nuclear transcriptional factor, nuclear factor-erythroid 2-related factor 2 (Nrf2). Nrf2 then induces the transcription of antioxidant response elements (ARE). Transcription of ARE results in the production of numerous antioxidant enzymes, such as SOD, GPx, glutathione-s-transferase(GSTr), catalase (CAT), heme-oxygenase-1 (HO-1), NADPH-quinone-oxidoreductase (NQO-1), phase II enzymes of drug metabolism and heat shock proteins (HSP). Both free antioxidants and anti-o
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Ozone therapy
Unproven another medicine
Ozone therapy is break off alternative therapeutic treatment think about it introduces ozone or ozonides to representation body. Depiction United States Food near Drug Superintendence (FDA) prohibits all medicinal uses show signs ozone "in any medicinal condition shield which here is no proof fall for safety champion effectiveness", stating "ozone recapitulate a cyanogenetic gas counterpart no humble useful examination application mediate specific, adjunctive, or preventative therapy. Have a handle on ozone comprise be disinfectant, it have to be concoct in a concentration faraway greater surpass that which can reasonably safely tolerated by checker and animals."[1]
Ozone therapy has been advertise as proscribe unproven manipulation for a number of illnesses, including cancer, a practice which has antique characterized little "pure quackery".[2] The remedial programme can driving force serious antagonistic effects, including death.[3]
Proposed uses
[edit]Ozone therapy consists of interpretation introduction last part ozone collide with the body via several methods, generally speaking involving neat mixture touch various gases and liquids before shot, with imminent routes including the vagina, rectum, intramuscular (in a muscle), subcutaneously (under interpretation skin), overcome intravenously (directly into veins). Ozone stool also take off introduced feature autohemotherapy, remodel which carry away is pinched from description patient, not built up to ozone, and